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The family comprised the consan-guineous parents and two affected children, suggesting autosomal recessive inheri-tance, even though the literature describes mainly sporadic and dominant cases [ 34 ].The work?ow included enrichment with Agilent SureSelect, sequencing on anIllumina Genome Analyzer, alignment with bwa [ 12], PCR duplicates marking withPicard [ 13], indel realignment, base-quality recalibration and variant calling withGATK [ 15], annotation with Annovar [ 16] and an in-house script for the calculationof homozygous regions using stretches of homozygous variations found in the WESdata. In the1960s and 1970s, molecular biology underwent huge growthas a scientific discipline.

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The historic St. Joseph church needed to be restored after damage caused by Hurricane Ivan rendered it unusable. The bell tower was repaired and a new roof structure was built and replaced. The original wood floor was dried, repaired and refinished, and the front door was salvaged, repaired and re-installed in its original location. The restoration of the church was completed and the church was rededicated by the Bishop on Christmas Eve, 2006.